To complete the "Canker" side quest in Kingdom Come: Deliverance 2, follow these steps:
Pick Up the Canker Side Quest
To initiate the "Canker" side quest, you need to have a conversation with Gules at Semine. You can easily pick up this quest during the wedding of Lord Semine and Agnes by talking to Gules beforehand while he's enjoying a drink. Alternatively, you can start the quest earlier by visiting Semine and speaking to Gules during his patrol. Ask him about his former bandit associates and offer your assistance in eliminating them. Canker is one of these bandits, and he becomes your first target.
Find and Kill Canker
Once you accept the quest, Canker's location will be marked on your map, situated north of Nebakov Mill. Be cautious as the path to this location is often patrolled by bandits who may attempt to ambush you. You can choose to sneak past them, engage in combat, or simply flee. While these random bandits are usually not formidable, it's best to avoid unnecessary fights to conserve your health for the upcoming battle.
Canker's bandit camp is nestled in the mountains, and it's easy to overlook as you need to navigate through a narrow gap to reach it, similar to accessing the Hermit's house during the "Wedding Crashers" quest. Prepare for combat before entering, as you'll encounter several bandits along with Canker.
In the ensuing fight, some bandits may flee depending on the order in which you defeat them. However, you must kill most of them, so don't assume you can avoid fighting all of them. Fortunately, Canker will not flee, ensuring you can complete your objective by killing him.
Finish the Quest and Return to Gules
After defeating Canker and his bandits, loot Canker's body to collect the Light Mace, which serves as proof of your success. Feel free to take any additional items from him as well. Once you have the mace, head back to Gules to complete the quest.
After successfully finishing the "Canker" quest in Kingdom Come: Deliverance 2, you'll need to wait a full in-game day before you can pick up the next quest related to Gules' former bandit companions. Once the day has passed, speak with Gules to start the "Handsome Charlie" quest.
